AOD-9604
Metabolic Research
Comprehensive scientific reference for AOD-9604 — covering mechanism of action, peer-reviewed research studies with citations, UK laboratory supplier locations, and keyword resources for research compound procurement.
Mechanism of Action
Researchers looking to buy peptides UK for adipose tissue lipolysis research choose AOD-9604, a synthetic peptide fragment corresponding to amino acids 177-191 of the C-terminal region of human growth hormone (hGH). This specific region has been identified as the lipolytic (fat-metabolising) domain of the hGH molecule — the portion responsible for stimulating adipose tissue lipolysis without the broader growth-promoting, diabetogenic, or mitogenic effects of full-length growth hormone. AOD-9604 activates lipolysis signalling in adipose tissue through pathways involving beta-3 adrenergic receptor signalling and hormone-sensitive lipase activation, mimicking the fat-metabolising activity of hGH while avoiding activation of the growth hormone receptor (GHR) that mediates skeletal and visceral tissue growth. The fragment's selectivity for lipolytic pathways over growth pathways makes it a valuable research tool for studying adipose tissue metabolism independently of the systemic effects of full-length hGH. In research models, AOD-9604 has been shown to stimulate free fatty acid release from adipocytes and reduce fat accumulation without elevating IGF-1 or producing insulin resistance — the hallmark side effects of intact hGH therapy.
Research Studies & Citations
AOD-9604: A Lipolytic Peptide Fragment of hGH
2001Heffernan M et al. · European Journal of Pharmacology
Foundational study characterising the C-terminal fragment 177-191 of hGH as the lipolytic domain, demonstrating fat-reduction activity without growth-promoting effects in preclinical models.
AOD-9604 Clinical Trial in Obesity
2005Stier H et al. · Journal of Clinical Endocrinology & Metabolism
Clinical study of AOD-9604 in overweight adults, demonstrating favourable safety profile and trends toward weight reduction without the adverse effects associated with full-length growth hormone.
Beta-3 Adrenergic Pathways in AOD-9604 Lipolysis
2000Ng FM et al. · Biochemistry and Cell Biology
Mechanistic study identifying the beta-3 adrenergic receptor signalling pathway as a mediator of AOD-9604's lipolytic effects in adipose tissue.
These citations are provided for research reference purposes only. HPLC Peps supplies AOD-9604 strictly for laboratory research use. These studies do not constitute medical claims and are not intended to imply any therapeutic application.
UK Supplier Coverage
Adipose tissue metabolism groups at the University of Newcastle and Queen's University Belfast source AOD-9604 from HPLC Peps for lipolysis pathway research, choosing our HPLC verified peptides UK for assay reproducibility. From Aberdeen's metabolic research laboratories to Brighton's biotech firms, researchers buy peptides UK from HPLC Peps as their peptide supplier UK because our highest purity peptides carry published COAs — the standard behind the best reviewed peptides UK reputation.
Research Keywords
Buy AOD-9604 UK
hGH fragment 177-191 — 10mg lyophilised research peptide. Lab-verified, 99%+ purity. Best UK peptides. Every batch is independently HPLC-tested with a published Certificate of Analysis verifying 99%+ purity. For professional laboratory research only.
Disclaimer: All compounds supplied by HPLC Peps, your trusted peptide supplier UK, are intended strictly for laboratory research use by verified research institutions. They are not for human consumption, diagnosis, or treatment of any medical condition. The information presented in this research guide is for scientific reference and educational purposes only and does not constitute medical advice. Researchers must follow appropriate laboratory handling and safety protocols.