CJC-1295 with DAC
Growth Hormone Research
Comprehensive scientific reference for CJC-1295 with DAC — covering mechanism of action, peer-reviewed research studies with citations, UK laboratory supplier locations, and keyword resources for research compound procurement.
Mechanism of Action
CJC-1295 with DAC (Drug Affinity Complex) is a modified growth hormone releasing hormone (GHRH) analogue engineered for extended half-life through a unique albumin-binding strategy. The peptide consists of the GHRH (1-29) sequence with four amino acid substitutions for DPP-4 resistance, plus a C-terminal Drug Affinity Complex (DAC) — a maleimidopropionyl-lysine moiety that forms a covalent thioether bond with serum albumin's Cys34 residue. This albumin conjugation extends the peptide's half-life from minutes to approximately 8 days, as albumin-bound CJC-1295 with DAC is protected from renal clearance and proteolytic degradation while retaining GHRH receptor (GHRHR) agonist activity. Upon binding GHRHR on pituitary somatotropes, CJC-1295 with DAC activates Galphas/cAMP/PKA signalling, stimulating both GH synthesis and sustained GH release. The extended half-life produces continuous (basal) GH elevation rather than the pulsatile pattern characteristic of short-acting GHRH analogues, making CJC-1295 with DAC a research tool for studying sustained GH pathway activation versus the pulsatile GH signalling modelled by shorter-acting GHRH analogues like CJC-1295 without DAC or sermorelin.
Research Studies & Citations
CJC-1295 with DAC: Albumin-Binding GHRH Analogue
2006Teichman SL et al. · Journal of Clinical Endocrinology & Metabolism
Study characterising the DAC albumin-binding modification and its effects on CJC-1295 half-life extension and sustained GH release.
Drug Affinity Complex and Peptide Half-Life Extension
2015Lau J et al. · Journal of Medicinal Chemistry
Mechanistic study of the DAC albumin-conjugation strategy for extending peptide pharmacokinetics.
Sustained vs Pulsatile GH Signalling: GHRH Analogue Comparison
2008Veldhuis JD et al. · Endocrine Reviews
Comparative study of sustained versus pulsatile GH release signalling, establishing the research rationale for long-acting GHRH analogues.
These citations are provided for research reference purposes only. HPLC Peps supplies CJC-1295 with DAC strictly for laboratory research use. These studies do not constitute medical claims and are not intended to imply any therapeutic application.
UK Supplier Coverage
Sustained GH signalling research at the University of Edinburgh and Cardiff University source CJC-1295 with DAC from HPLC Peps for albumin-binding pharmacokinetic studies, selecting HPLC verified peptides UK for consistent long-duration GH assay data. From Newcastle's endocrine laboratories to Sheffield's pituitary research groups, researchers buy peptides UK from HPLC Peps as their peptide supplier UK because our highest purity peptides carry published COAs confirming 99%+ purity.
Research Keywords
Buy CJC-1295 with DAC UK
GHRH analogue with DAC — 10mg lyophilised research peptide. Lab-verified, 99%+ purity. Best UK peptides. Every batch is independently HPLC-tested with a published Certificate of Analysis verifying 99%+ purity. For professional laboratory research only.
Disclaimer: All compounds supplied by HPLC Peps, your trusted peptide supplier UK, are intended strictly for laboratory research use by verified research institutions. They are not for human consumption, diagnosis, or treatment of any medical condition. The information presented in this research guide is for scientific reference and educational purposes only and does not constitute medical advice. Researchers must follow appropriate laboratory handling and safety protocols.