PT-141 (Bremelanotide)
Melanocortin Research
Comprehensive scientific reference for PT-141 (Bremelanotide) — covering mechanism of action, peer-reviewed research studies with citations, UK laboratory supplier locations, and keyword resources for research compound procurement.
Mechanism of Action
PT-141 (Bremelanotide) is a synthetic heptapeptide melanocortin receptor agonist (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH) derived from the melanotan II peptide structure. Unlike melanotan II, which is a non-selective agonist across MC1R-MC5R, PT-141 exhibits selectivity for the MC3R and MC4R receptors — the central melanocortin receptors expressed in the hypothalamus and limbic system that are involved in sexual function signalling. The MC3R/MC4R selectivity is significant: it separates PT-141's sexual function signalling activity from the MC1R-mediated melanogenesis (pigmentation) that characterises melanotan II, making PT-141 a cleaner research tool for studying central melanocortin signalling in sexual function without significant pigmentation effects. Upon MC3R/MC4R activation, PT-141 stimulates Galphas/cAMP signalling in hypothalamic and limbic neurons, activating the melanocortin signalling pathways that modulate sexual arousal and behaviour. The mechanism is distinct from phosphodiesterase inhibitors (which act on vascular NO/cGMP pathways): PT-141 acts centrally on melanocortin signalling, providing a different pharmacological approach to sexual function research and making it a valuable tool for studying the central melanocortin regulation of sexual behaviour.
Research Studies & Citations
PT-141: MC3R/MC4R Selective Melanocortin Agonism
2003Molinoff PB et al. · Journal of Sexual Medicine
Study characterising PT-141's selectivity for MC3R and MC4R and its central melanocortin signalling in sexual function.
Central Melanocortin Signalling in Sexual Function
2010Argiolas A et al. · Neuroscience & Biobehavioral Reviews
Review of MC3R/MC4R signalling in hypothalamic and limbic regulation of sexual behaviour, providing mechanistic context for PT-141.
PT-141 vs Melanotan II: Receptor Selectivity Comparison
2001Hadley ME et al. · Journal of Pharmacology and Experimental Therapeutics
Comparative study of PT-141 and melanotan II, characterising PT-141's MC3R/MC4R selectivity versus melanotan II's broader MC1R-MC5R activity.
These citations are provided for research reference purposes only. HPLC Peps supplies PT-141 (Bremelanotide) strictly for laboratory research use. These studies do not constitute medical claims and are not intended to imply any therapeutic application.
UK Supplier Coverage
Central melanocortin and sexual function signalling research at the University of Manchester and the University of Glasgow source PT-141 from HPLC Peps for MC3R/MC4R selectivity studies, choosing HPLC verified peptides UK for reproducible central signalling assay data. From Newcastle's hypothalamic research groups to Sheffield's neuropharmacology laboratories, researchers buy peptides UK from HPLC Peps as their peptide supplier UK because our highest purity peptides carry published COAs confirming 99%+ purity.
Research Keywords
Buy PT-141 (Bremelanotide) UK
Melanocortin receptor agonist (Bremelanotide) — 20mg lyophilised research peptide. Lab-verified, 99%+ purity. Best UK peptides. Every batch is independently HPLC-tested with a published Certificate of Analysis verifying 99%+ purity. For professional laboratory research only.
Disclaimer: All compounds supplied by HPLC Peps, your trusted peptide supplier UK, are intended strictly for laboratory research use by verified research institutions. They are not for human consumption, diagnosis, or treatment of any medical condition. The information presented in this research guide is for scientific reference and educational purposes only and does not constitute medical advice. Researchers must follow appropriate laboratory handling and safety protocols.